Ultrasound-enhanced mass transfer during single-bubble diffusive growth

Ultrasound is known to enhance surface bubble growth and removal in catalytic and microfluidic applications, yet the contributions of rectified diffusion and microstreaming phenomena towards mass transfer remain unclear. We quantify the effect of ultrasound on the diffusive growth of a single spherical CO$_2$ bubble growing on a substrate in supersaturated water. The time dependent bubble size, shape, oscillation amplitude and microstreaming flow field are resolved. We show and explain how ultrasound can enhance the diffusive growth of surface bubbles by up to two orders of magnitude during volumetric resonance. The proximity of the wall forces the bubble to oscillate non-spherically, thereby generating vigorous streaming during resonance that results in convection-dominated growth.Comment: Accepted in Phys. Rev. Fluid

Plasmonic Bubbles in n-Alkanes

In this paper we study the formation of microbubbles upon the irradiation of an array of plasmonic Au nanoparticles with a laser in n-alkanes ($C_{n}H_{2n+2}$, with n = 5-10). Two different phases in the evolution of the bubbles can be distinguished. In the first phase, which occurs after a delay time {\tau}d of about 100 {\mu}s, an explosive microbubble, reaching a diameter in the range from 10 {\mu}m to 100 {\mu}m, is formed. The exact size of this explosive microbubble barely depends on the carbon chain length of the alkane, but only on the laser power $P_l$. With increasing laser power, the delay time prior to bubble nucleation as well as the size of the microbubble both decrease. In the second phase, which sets in right after the collapse of the explosive microbubble, a new bubble forms and starts growing due to the vaporization of the surrounding liquid, which is highly gas rich. The final bubble size in this second phase strongly depends on the alkane chain length, namely it increases with decreasing number of carbon atoms. Our results have important implications for using plasmonic heating to control chemical reactions in organic solvents

The role of ultrasound-driven microbubble dynamics in drug delivery : from microbubble fundamentals to clinical translation

In the last couple of decades, ultrasound-driven microbubbles have proven excellent candidates for local drug delivery applications. Besides being useful drug carriers, microbubbles have demonstrated the ability to enhance cell and tissue permeability and, as a consequence, drug uptake herein. Notwithstanding the large amount of evidence for their therapeutic efficacy, open issues remain. Because of the vast number of ultrasound- and microbubble-related parameters that can be altered and the variability in different models, the translation from basic research to (pre)clinical studies has been hindered. This review aims at connecting the knowledge gained from fundamental microbubble studies to the therapeutic efficacy seen in in vitro and in vivo studies, with an emphasis on a better understanding of the response of a microbubble upon exposure to ultrasound and its interaction with cells and tissues. More specifically, we address the acoustic settings and microbubble-related parameters (i.e., bubble size and physicochemistry of the bubble shell) that play a key role in microbubble cell interactions and in the associated therapeutic outcome. Additionally, new techniques that may provide additional control over the treatment, such as monodisperse microbubble formulations, tunable ultrasound scanners, and cavitation detection techniques, are discussed. An in-depth understanding of the aspects presented in this work could eventually lead the way to more efficient and tailored microbubble-assisted ultrasound therapy in the future

Insights into acoustically induced piezoluminescence : the visualization of ultrasonic beam patterns

Ultrasonic transducers are used in many fields of application, including medical imaging/treatment, non-destructive testing and material characterization. To assure the quality of the ultrasonic investigation transducers require regular checks for possible deterioration and accurate calibration. Current methods rely on point-by-point scanning of the ultrasound field with a needle hydrophone, which is expensive and time consuming. Recently, we have developed a new concept, in which a fast full-field visualization of the radiation field is achieved through Acoustically induced PiezoLuminescence (APL). Here, we report on an improved ultrasonic beam visualization and provide further insights into the mechanism underlying APL and mechanoluminescence

Time-resolved velocity and pressure field quantification in a flow-focusing device for ultrafast microbubble production

Flow-focusing devices have gained great interest in the past decade, due to their capability to produce monodisperse microbubbles for diagnostic and therapeutic medical ultrasound applications. However, up-scaling production to industrial scale requires a paradigm shift from single chip operation to highly parallelized systems. Parallelization gives rise to fluidic interactions between nozzles that, in turn, may lead to a decreased monodispersity. Here, we study the velocity and pressure field fluctuations in a single flow-focusing nozzle during bubble production. We experimentally quantify the velocity field inside the nozzle at 100 ns time resolution, and a numerical model provides insight into both the oscillatory velocity and pressure fields. Our results demonstrate that, at the length scale of the flow focusing channel, the velocity oscillations propagate at fluid dynamical time scale (order of microseconds) whereas the dominant pressure oscillations are linked to the bubble pinch-off and propagate at a much faster time scale (order of nanoseconds).Comment: 30 pages, 7 figure

Inverse Leidenfrost drop manipulation using menisci

Drops deposited on an evaporating liquid bath can be maintained in an inverse Leidenfrost state by the vapor emanating from the bath, making them levitate and hover almost without friction. These perfectly non-wetting droplets create a depression in the liquid interface that sustains their weight, which generates repellent forces when they approach a meniscus rising against a wall. Here, we study this reflection in detail, and show that frictionless Leidenfrost drops are a simple and efficient tool to probe the shape of an unknown interface. We then use the menisci to control the motion of the otherwise elusive drops. We create waveguides to direct and accelerate them and use parabolic walls to reflect and focus them. This could be particularly beneficial in the scale up of droplet cryopreservation processes: capillary interactions can be used to transport, gather and collect vitrified biological samples in absence of contact and contamination

Transverse flow under oscillating stimulation in helical square ducts with cochlea-like geometrical curvature and torsion

The cochlea is our fluid-filled organ of hearing with a unique spiral shape. The physiological role of this shape remains unclear. Previous research has paid only little attention to the occurrence of transverse flow in the cochlea, in particular in relation to the cochlea's shape. To better understand its influence on fluid dynamics, this study aims to characterize transverse flow due to harmonically oscillating axial flow in square ducts with curvature and torsion, similar to the shape of human cochleae. Four geometries were investigated to study curvature and torsion effects on axial and transverse fluid flow components. Twelve frequencies from 0.125 Hz to 256 Hz were studied, covering infrasound and low-frequency hearing, with mean inlet velocity amplitudes representing levels expected for normal conversations or louder situations. Our simulations show that torsion contributes significantly to transverse flow in unsteady conditions, and that its contribution increases with increasing oscillation frequencies. Curvature has a small effect on transverse flow, which decreases rapidly for increasing frequencies. Strikingly, the combined effect of curvature and torsion on transverse flow is greater than expected from a simple superposition of the two effects, especially when the relative contribution of curvature alone becomes negligible. These findings could be relevant to understand physiological processes in the cochlea, including metabolite transport and wall shear stresses. Further studies are needed to investigate possible implications on cochlear mechanics.Comment: 26 pages, 7 figure

Monodisperse versus polydisperse ultrasound contrast agents: nonlinear response, sensitivity, and deep tissue imaging potential

Monodisperse microbubble ultrasound contrast agents have been proposed to further increase the signal-to-noise-ratio of contrast enhanced ultrasound imaging. Here, the sensitivity of a polydisperse preclinical agent was compared experimentally to that of its size- and acoustically-sorted derivatives by using narrowband pressure- and frequency-dependent scattering and attenuation measurements. The sorted monodisperse agents showed up to a two orders of magnitude increase in sensitivity, i.e. in the average scattering cross-section per bubble. Moreover, we demonstrate here, for the first time, that the highly nonlinear response of acoustically sorted microbubbles can be exploited to confine scattering and attenuation to the focal region of ultrasound fields used in clinical imaging. This property is a result of minimal prefocal scattering and attenuation and can be used to minimize shadowing effects in deep tissue imaging. Moreover, it potentially allows for more localized therapy using microbubbles through the spatial control of resonant microbubble oscillations